Amphiregulin
C Berasain, MA Avila - Seminars in cell & developmental biology, 2014 - Elsevier
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely
expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored …
expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored …
The epidermal growth factor receptor ligands at a glance
MR Schneider, E Wolf - Journal of cellular physiology, 2009 - Wiley Online Library
The epidermal growth factor receptor (EGFR) regulates key processes of cell biology,
including proliferation, survival, and differentiation during development, tissue homeostasis …
including proliferation, survival, and differentiation during development, tissue homeostasis …
Angiogenic factors in bone local environment
Angiogenesis plays an important role in physiological bone growth and remodeling, as well
as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor …
as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor …
The multiple roles of amphiregulin in human cancer
Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR).
AREG plays a central role in mammary gland development and branching morphogenesis …
AREG plays a central role in mammary gland development and branching morphogenesis …
Lung cancer preneoplasia
II Wistuba, AF Gazdar - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
From histological and biological perspectives, lung cancer is a complex neoplasm. Although
the sequential preneoplastic changes have been defined for centrally arising squamous …
the sequential preneoplastic changes have been defined for centrally arising squamous …
[HTML][HTML] Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease
AS Dusso, M Tokumoto - Kidney international, 2011 - Elsevier
In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D
hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and …
hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and …
EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation
Osteoarthritis (OA) is the most common joint disease, characterized by progressive
destruction of the articular cartilage. The surface of joint cartilage is the first defensive and …
destruction of the articular cartilage. The surface of joint cartilage is the first defensive and …
Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression
Maintaining bone architecture requires continuous generation of osteoblasts from
osteoprogenitor pools. Our previous study of mice with epidermal growth factor receptor …
osteoprogenitor pools. Our previous study of mice with epidermal growth factor receptor …
Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology
MR Schneider, S Werner, R Paus, E Wolf - The American journal of …, 2008 - Elsevier
The epidermal growth factor receptor (EGFR) network, including its seven ligands and four
related receptors, represents one of the most complex signaling systems in biology. In many …
related receptors, represents one of the most complex signaling systems in biology. In many …
Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis
Parathyroid hormone (PTH) stimulates bone formation when injected daily but causes
severe bone loss with continuous infusion. The mechanism of its paradoxical effects is still …
severe bone loss with continuous infusion. The mechanism of its paradoxical effects is still …