Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Metalloenzymes have been detailed in The Enzymes since its inception over half a century
ago. Here, I review selected metal-containing enzyme highlights from early chapters in this …

PtlD, a multifunctional mononuclear nonheme iron and α-ketoglutarate-dependent (NHFe/α-
KG) dioxygenase involved in neopentalenoketolactone biosynthesis, catalyzes …

The isocyanide group is the chameleon among the functional groups in organic chemistry.
Unlike other multiatom functional groups, where the electrophilic and nucleophilic moieties …

Although recognized earlier as subcellular entities by microscopists, mitochondria have
been the subject of functional studies since 1922, when their biochemical similarities with …

ABSTRACT Non-heme Fe (II)/α-ketoglutarate (αKG)-dependent enzymes catalyze numerous
C–H activation and functionalization reactions. However, how αKG-dependent non-heme …

Geminal, multi-halogenated functional groups are widespread in natural products and
pharmaceuticals, yet no synthetic methodologies exist that enable selective multi …

Cyanobacteria are a diverse group of photosynthetic microorganisms known for their
production of bioactive compounds with various biological activities. This review explores …

Cyanobacteria are a diverse group of photosynthetic microorganisms known for their
production of bioactive compounds with various biological activities. This review explores …