The oligomer hypothesis in α-synucleinopathy

K Ono - Neurochemical Research, 2017 - Springer
Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of
Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils …

Amyloid β-interacting partners in Alzheimer's disease: from accomplices to possible therapeutic targets

SH Han, JC Park, I Mook-Jung - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in
modern society because of insurmountable difficulties in early diagnosis and lack of …

CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease

M Noguchi-Shinohara, T Tokuda, M Yoshita, T Kasai… - Brain research, 2009 - Elsevier
Dementia with Lewy bodies (DLB) is characterized by widespread depositions of α-
synuclein, which are described as Lewy bodies. Recently, it was shown that neuronal cells …

Development and assessment of sensitive immuno‐PCR assays for the quantification of cerebrospinal fluid three‐and four‐repeat tau isoforms in tauopathies

C Luk, Y Compta, N Magdalinou… - Journal of …, 2012 - Wiley Online Library
Characteristic tau isoform composition of the insoluble fibrillar tau inclusions define
tauopathies, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and …

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies

AT Marvian, DJ Koss, F Aliakbari… - Journal of …, 2019 - Wiley Online Library
Alpha‐synuclein (α‐S yn) is a central player in Parkinson's disease (PD) and in a spectrum
of neurodegenerative diseases collectively known as synucleinopathies. The protein was …

Anti-aggregation and fibril-destabilizing effects of sex hormones on α-synuclein fibrils in vitro

M Hirohata, K Ono, A Morinaga, T Ikeda… - Experimental neurology, 2009 - Elsevier
The α-synuclein aggregation in the brain is the hallmark of Lewy body diseases, including
Parkinson's disease and dementia with Lewy bodies, and multiple system atrophy. Some …

β-Synuclein Assembly as a Therapeutic Target of Parkinson's Disease and Related Disorders

K Ono, M Hirohata, M Yamada - Current Pharmaceutical …, 2008 - ingentaconnect.com
Lewy bodies (LBs) and Lewy neurites (LNs) in the brain constitute the main
histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies …

[HTML][HTML] Cerebrospinal fluid biomarkers for dementia with lewy bodies

EB Mukaetova-Ladinska, R Monteith… - International Journal of …, 2010 - hindawi.com
More than 750,000 of the UK population suffer from some form of cognitive impairment and
dementia. Of these, 5–20% will have Dementia with Lewy Bodies (DLB). Clinico …

Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation

M Hirohata, K Ono, A Morinaga, T Ikeda, M Yamada - Neuroscience letters, 2011 - Elsevier
The aggregation of α-synuclein (αS) in the central nervous system (CNS) is the hallmark of
multiple system atrophy (MSA) and Lewy body diseases including Parkinson's disease (PD) …

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer's disease

Z Gažová, A Antošová, Z Krištofiková, A Bartoš… - Molecular …, 2010 - pubs.rsc.org
It is well known that oligomeric/aggregated amyloid β peptides are a key player in the
pathogenesis of Alzheimer's disease and that different nanoparticles influence …