Oxidative stress in multiple sclerosis: Central and peripheral mode of action

K Ohl, K Tenbrock, M Kipp - Experimental neurology, 2016 - Elsevier
Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead …

Emerging understanding of the mechanism of action for dimethyl fumarate in the treatment of multiple sclerosis

EA Mills, MA Ogrodnik, A Plave… - Frontiers in neurology, 2018 - frontiersin.org
Dimethyl fumarate (DMF) is an effective treatment option for relapsing–remitting multiple
sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. A …

EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris–Part 1: treatment and monitoring recommendations

A Nast, C Smith, PI Spuls, G Avila Valle… - Journal of the …, 2020 - Wiley Online Library
This evidence‐and consensus‐based guideline on the treatment of psoriasis vulgaris was
developed following the EuroGuiDerm Guideline and Consensus Statement Development …

EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris–Part 2: specific clinical and comorbid situations

A Nast, C Smith, PI Spuls, G Avila Valle… - Journal of the …, 2021 - Wiley Online Library
This evidence‐and consensus‐based guideline on the treatment of psoriasis vulgaris was
developed following the EuroGuiDerm Guideline and Consensus Statement Development …

Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned

EO Major, TA Yousry, DB Clifford - The Lancet Neurology, 2018 - thelancet.com
Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating
disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised …

Disease-modifying therapies and infectious risks in multiple sclerosis

A Winkelmann, M Loebermann, EC Reisinger… - Nature Reviews …, 2016 - nature.com
Immunomodulatory and immunosuppressive treatments for multiple sclerosis (MS) are
associated with an increased risk of infection, which makes treatment of this condition …

Update on disease-modifying therapies for multiple sclerosis

DL Vargas, WR Tyor - Journal of Investigative Medicine, 2017 - journals.sagepub.com
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous
system (CNS). It predominantly affects young women and is one of the most common causes …

Dimethyl fumarate selectively reduces memory T cells and shifts the balance between Th1/Th17 and Th2 in multiple sclerosis patients

QI Wu, Q Wang, G Mao, CA Dowling… - The Journal of …, 2017 - journals.aai.org
Dimethyl fumarate (DMF; trade name Tecfidera) is an oral formulation of the fumaric acid
ester that is Food and Drug Administration approved for treatment of relapsing-remitting …

Risks and risk management in modern multiple sclerosis immunotherapeutic treatment

L Klotz, J Havla, N Schwab, R Hohlfeld… - Therapeutic …, 2019 - journals.sagepub.com
In recent years, there has been a paradigm shift in the treatment of multiple sclerosis (MS)
owing to the approval of a number of new drugs with very distinct mechanisms of action. All …

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

RA Linker, A Haghikia - Therapeutic advances in chronic …, 2016 - journals.sagepub.com
Dimethyl fumarate (DMF) is one of the newer additions to the armamentarium of potent
immunomodulators for the treatment of relapsing-remitting multiple sclerosis (RRMS). After …