As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Studies have demonstrated that scaffolds, a component of bone tissue engineering, play an
indispensable role in bone repair. However, these scaffolds involving ex-vivo cultivated cells …

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …

Abstract Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and
their plasticity in relationship to bone growth, articulation, and formation of the trabeculae …

Endochondral ossification (ECO), the major ossification process during embryogenesis and
bone repair, involves the formation of a cartilaginous template remodelled into a functional …

The sea cucumber intestine is a major by-product of sea cucumber processing and contains
high levels of protein. In this study, we isolated and identified 28 novel osteogenic peptides …

Abstract Purpose of Review Proper cartilage development is critical to bone formation during
endochondral ossification. This review highlights the current understanding of various …

Cell fate determination of human mesenchymal stem/stromal cells (hMSCs) is precisely
regulated by lineage-specific transcription factors and epigenetic enzymes. We found that …

The vertebrate musculoskeletal system is known to be formed by mesenchymal stem cells
condensing into tissue elements, which then differentiate into cartilage, bone …

ABSTRACT BMP2 stimulates bone formation and signals preferably through BMP receptor
(BMPR) 1A, whereas GDF5 is a cartilage inducer and signals preferably through BMPR1B …