Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …

The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Mitochondria are dynamic organelles that undergo membrane remodeling events in
response to metabolic alterations to generate an adequate mitochondrial network. Here, we …

Abstract Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …

As organisms develop, individual cells generate mitochondria to fulfill physiological
requirements. However, it remains unknown how mitochondrial network expansion is scaled …