In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

A better knowledge of the complex interactions between cancer cells and the immune
system has led to novel immunotherapy approaches. Treatment with selective anti-PD1, anti …

Pancreatic cancer is the fourth leading cause of cancer-related death among men and
women in the United States. A major challenge in treatment remains patients' advanced …

PURPOSE Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing
has traditionally been performed in patients with colorectal (CRC) and endometrial cancer …

Importance Hereditary cancer syndromes infer high cancer risks and require intensive
cancer surveillance, yet the prevalence and spectrum of these conditions among unselected …

Identifying individuals with hereditary syndromes allows for improved cancer surveillance,
risk reduction, and optimized management. Establishing criteria for assessment allows for …

Purpose Hereditary factors play an important role in colorectal cancer (CRC) risk, yet the
prevalence of germline cancer susceptibility gene mutations in patients with CRC …

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying
individuals at low and high risk of developing CRC, as they can then be offered targeted …

Microsatellite instability (MSI) has been approved as a pan-cancer biomarker for immune
checkpoint blockade (ICB) therapy. However, current MSI identification methods are not …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …