Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

Target-identification and mechanism-of-action studies have important roles in small-
molecule probe and drug discovery. Biological and technological advances have resulted in …

Targeted protein degradation is a new therapeutic modality based on drugs that destabilize
proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are …

INTRODUCTION Understanding drug mechanism poses the daunting challenge of
determining the affinity of the drug for all potential targets. Drug target engagement can be …

Abstract Background and Objective In clinical practice, injectable drug combination (IDC)
usually provides good therapeutic effects for patients. Numerous clinical studies have …

Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell
(HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has …

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder arising in the
haemopoietic stem cell (HSC) compartment. This disease is characterised by a reciprocal t …

Highlights•Review of the state-of-the-art in the field of compound combination modelling.•
Significance of quality control of large-scale combination screening data.•Strategies for …

Motivation: Drug combinations are a promising strategy for combating complex diseases by
improving the efficacy and reducing corresponding side effects. Currently, a widely studied …

Drug combination is a sensible strategy for disease treatment because it improves the
treatment efficacy and reduces concomitant side effects. Due to the large number of possible …