The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …

Cell proliferation, cell death, and pattern formation are coordinated in animal development.
Although many proteins that control cell proliferation and apoptosis have been identified, the …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

The Wnt signaling pathways have been conserved throughout evolution and regulate cell
proliferation, morphology, motility, and fate during embryonic development. These pathways …

Wnts are secreted signaling molecules that can transduce their signals through several
different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by …

Virtually every aspect of cellular function within a metazoan organism, including proliferative
status, metabolism, gene expression, cytoskeletal organization, and indeed the cell's very …

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …

The c-Jun NH2-terminal kinase (JNK) is a member of an evolutionarily conserved sub-family
of mitogen-activated protein (MAP) kinases. Recent studies have led to progress towards …

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce
committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an …