The platelet‑derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a
balance between liver repair and progressive substitution of the liver parenchyma by scar …

Liver fibrosis is the most common final outcome for chronic liver diseases. The complex
pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe …

Matrix metalloproteinases (MMPs) are proteinases capable of degrading components of the
extracellular matrix and numerous nonmatrix proteins. MMPs along with tissue inhibitors of …

Hepatic fibrosis (HF) refers to the pathophysiological process of connective tissue dysplasia
in the liver caused by various pathogenic factors. Nowadays, HF is becoming a severe threat …

Aim To investigate the effect of carvedilol on liver fibrosis and hepatic sinusoidal
capillarization in mice with carbon tetrachloride (CCl4)-induced fibrosis. Methods A liver …

Headings ethnopharmacological relevance Corilagin (β-1-O-galloyl-3, 6-(R)-
hexahydroxydiphenoyl-d-glucose) is a tannin isolated from the traditional …

Alcoholic liver disease (ALD) is a broad category of disorders that begin with liver injury,
lead to liver fibrosis, and ultimately conclude in alcohol-induced liver cirrhosis, the most …

Alcoholic liver disease (ALD) is a growing global health concern, and its early pathogenesis
includes steatosis and steatohepatitis. Inhibiting lipid accumulation and inflammation is a …

Aims Endotoxemia and its pro-fibrogenic signaling play a significant role in the development
of hepatic fibrosis. This study investigated whether lipopolysaccharide (LPS) directly activate …