Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes
L Björnström, M Sjöberg - Molecular endocrinology, 2005 - academic.oup.com
Estrogen receptors (ERs) act by regulating transcriptional processes. The classical
mechanism of ER action involves estrogen binding to receptors in the nucleus, after which …
mechanism of ER action involves estrogen binding to receptors in the nucleus, after which …
Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
AR Black, JD Black… - Journal of cellular …, 2001 - Wiley Online Library
The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
The role of Sp1 and Sp3 in normal and cancer cell biology
L Li, JR Davie - Annals of Anatomy-Anatomischer Anzeiger, 2010 - Elsevier
Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are
involved in regulating the transcriptional activity of genes implicated in most cellular …
involved in regulating the transcriptional activity of genes implicated in most cellular …
Genomic targets of nuclear estrogen receptors
R O'Lone, MC Frith, EK Karlsson… - Molecular …, 2004 - academic.oup.com
Estrogen influences the physiology of many target tissues in both women and men. The long-
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …
[HTML][HTML] Nonclassical genomic ER/Sp and ER/AP-1 signaling pathways
Abstract 17β-Estradiol (E2) binds to the estrogen receptor (ER) to activate gene expression
or repression and this involves both genomic (nuclear) and non-genomic (extranuclear …
or repression and this involves both genomic (nuclear) and non-genomic (extranuclear …
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17β-estradiol and hydroxytamoxifen in endometrial cancer cells
A Vivacqua, D Bonofiglio, AG Recchia… - Molecular …, 2006 - academic.oup.com
The growth of both normal and transformed epithelial cells of the female reproductive system
is stimulated by estrogens, mainly through the activation of estrogen receptor α (ERα), which …
is stimulated by estrogens, mainly through the activation of estrogen receptor α (ERα), which …
STAT3: a critical transcription activator in angiogenesis
Z Chen, ZC Han - Medicinal research reviews, 2008 - Wiley Online Library
Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a
complex multistage process regulated by a number of signal transduction pathways …
complex multistage process regulated by a number of signal transduction pathways …
Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis
Z von Marschall, A Scholz, T Cramer… - Journal of the …, 2003 - academic.oup.com
Background: Interferon alpha (IFN-α) has antiangiogenic activity, although the underlying
mechanism of action is unclear. Because human neuroendocrine (NE) tumors are highly …
mechanism of action is unclear. Because human neuroendocrine (NE) tumors are highly …
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells
Sp proteins play an important role in angiogenesis and growth of cancer cells, and
specificity protein 1 (Sp1) has been linked to vascular endothelial growth factor (VEGF) …
specificity protein 1 (Sp1) has been linked to vascular endothelial growth factor (VEGF) …
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements
Cyclin D1 gene expression is induced by 17β-estradiol (E2) in human breast cancer cells
and is important for progression of cells through the G 1 phase of the cell cycle. The …
and is important for progression of cells through the G 1 phase of the cell cycle. The …