Probing perceptual decisions in rodents

M Carandini, AK Churchland - Nature neuroscience, 2013 - nature.com
The study of perceptual decision-making offers insight into how the brain uses complex,
sometimes ambiguous information to guide actions. Understanding the underlying …

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

CA Orsini, DE Moorman, JW Young, B Setlow… - Neuroscience & …, 2015 - Elsevier
Over the past 20 years there has been a growing interest in the neural underpinnings of
cost/benefit decision-making. Recent studies with animal models have made considerable …

Distributed coding of choice, action and engagement across the mouse brain

NA Steinmetz, P Zatka-Haas, M Carandini, KD Harris - Nature, 2019 - nature.com
Vision, choice, action and behavioural engagement arise from neuronal activity that may be
distributed across brain regions. Here we delineate the spatial distribution of neurons …

A synaptic threshold mechanism for computing escape decisions

DA Evans, AV Stempel, R Vale, S Ruehle, Y Lefler… - Nature, 2018 - nature.com
Escaping from imminent danger is an instinctive behaviour that is fundamental for survival,
and requires the classification of sensory stimuli as harmless or threatening. The absence of …

Striatal indirect pathway mediates exploration via collicular competition

J Lee, BL Sabatini - Nature, 2021 - nature.com
The ability to suppress actions that lead to a negative outcome and explore alternative
actions is necessary for optimal decision making. Although the basal ganglia have been …

Sensorimotor decision making in the zebrafish tectum

AJ Barker, H Baier - Current Biology, 2015 - cell.com
An animal's survival depends on its ability to correctly evaluate sensory stimuli and select
appropriate behavioral responses. When confronted with ambiguous stimuli, the brain is …

A brain-wide map of neural activity during complex behaviour

International Brain Laboratory, B Benson, J Benson… - Biorxiv, 2023 - biorxiv.org
A key challenge in neuroscience is understanding how neurons in hundreds of
interconnected brain regions integrate sensory inputs with prior expectations to initiate …

Cortical and subcortical contributions to short-term memory for orienting movements

CD Kopec, JC Erlich, BW Brunton, K Deisseroth… - Neuron, 2015 - cell.com
Neural activity in frontal cortical areas has been causally linked to short-term memory (STM),
but whether this activity is necessary for forming, maintaining, or reading out STM remains …

Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements

J Essig, JB Hunt, G Felsen - Communications Biology, 2021 - nature.com
Decision making is a cognitive process that mediates behaviors critical for survival.
Choosing spatial targets is an experimentally-tractable form of decision making that …

Topography of a visuomotor transformation

TO Helmbrecht, M Dal Maschio, JC Donovan… - Neuron, 2018 - cell.com
The brain converts perceptual information into appropriate patterns of muscle activity
depending on the categorization and localization of sensory cues. Sensorimotor information …