Alzheimer's disease (AD) is the most common progressive neurodegenerative disease.
Today, AD affects millions of people worldwide and the number of AD cases will increase …

Abnormal posttranslational modifications of tau protein lead it to aggregate into paired
helical filaments in Alzheimer's disease (AD). The mechanisms involved in the early …

Objective We tested the hypothesis that eradication of Helicobacter pylori infection (Hp-I)
could improve survival in a Greek cohort of AD patients, in a 5-year follow-up. Method Forty …

One of the central lesions in the brain of subjects with Alzheimer's disease (AD) is
represented by aggregates of β-amyloid (Aβ), a peptide of 40–42 amino acids derived from …

Mouse models of Alzheimer's disease (AD) show progression through stages reflective of
human pathology. Proteomics identification of temporal and sex-linked factors driving AD …

Platelets are the first peripheral source of amyloid precursor protein (APP). They possess the
proteolytic machinery to produce Aβ and fragments similar to those produced in neurons …

Platelets contribute to 95% of circulating amyloid precursor protein in the body and have
widely been employed as a “peripheral” model of neurons in Alzheimer's disease. We …

Fragile X syndrome (FXS) is the most prevalent monogenic cause of intellectual disability
and autism spectrum disorder (ASD). Affected individuals have a high prevalence of …

In Alzheimer's disease (AD), molecular changes are observed not only in patients' neurons
but also in peripheral cells, such as blood lymphocytes. These include changes in the level …

Alzheimer's disease is an age-dependent neurodegenerative disorder characterized by loss
of neurons, synaptic degeneration, senile plaques and neurofibrillary tangles. Besides these …