Inhibition of cellular and animal inflammatory disease models by NF-κB inhibitor DHMEQ

J Ma, Y Zhang, T Sugai, T Kubota, H Keino, M El-Salhy… - Cells, 2021 - mdpi.com
General inflammatory diseases include skin inflammation, rheumatoid arthritis, inflammatory
bowel diseases, sepsis, arteriosclerosis, and asthma. Although these diseases have been …

Inhibition of late and early phases of cancer metastasis by the NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: a review

Y Lin, T Ukaji, N Koide, K Umezawa - International Journal of Molecular …, 2018 - mdpi.com
We previously designed and synthesized dehydroxyepoxyquinomicin (DHMEQ) as an
inhibitor of NF-κB based on the structure of microbial secondary metabolite epoxyquinomicin …

Molecular Mechanism of Equine Endometrosis: The NF-κB-Dependent Pathway Underlies the Ovarian Steroid Receptors' Dysfunction

T Jasiński, Ł Zdrojkowski, G Ferreira-Dias… - International Journal of …, 2022 - mdpi.com
Endometrosis is a frequently occurring disease decreasing mares' fertility. Thus, it is an
important disease of the endometrium associated with epithelial and stromal cell alterations …

Expression of genes involved in the NF-κB-dependent pathway of the fibrosis in the mare endometrium

M Domino, T Jasinski, E Kautz, E Juszczuk-Kubiak… - Theriogenology, 2020 - Elsevier
Equine endometrosis is a multifactorial chronic degenerative condition, considered to be
one of a major causes of equine infertility. The formation of periglandular fibrosis seems to …

Equine endometrosis pathological features: Are they dependent on NF-κB Signaling pathway?

T Jasiński, Ł Zdrojkowski, E Kautz, E Juszczuk-Kubiak… - Animals, 2021 - mdpi.com
Simple Summary Endometrosis is a serious problem mainly affecting older mares' fertility.
Despite the importance of this disease, its etiology and pathogenesis are not fully known …

Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma

H Su, R Zou, J Su, X Chen, H Yang, N An… - Frontiers in …, 2024 - frontiersin.org
Peritoneal dialysis is a widely used method for treating kidney failure. However, over time,
the peritoneal structure and function can deteriorate, leading to the failure of this therapy …

[HTML][HTML] Anticancer activity of novel NF-κB inhibitor DHMEQ by intraperitoneal administration

K Umezawa, A Breborowicz, S Gantsev - Oncology Research, 2020 - ncbi.nlm.nih.gov
There have been great advances in the therapy of cancer and leukemia. However, there are
still many neoplastic diseases that are difficult to treat. For example, it is often difficult to find …

[HTML][HTML] Inhibition of MLCK‑mediated migration and invasion in human endometriosis stromal cells by NF‑κB inhibitor DHMEQ

Y Lin, S Kojima, A Ishikawa… - Molecular …, 2023 - spandidos-publications.com
Endometriosis is initiated by the movement of endometrial cells in the uterus to the fallopian
tubes, the ovaries and the peritoneal cavity after the shedding of the uterus lining. To cause …

Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice

C Qian, Q Yang, L Guo, H Zhu… - Experimental and …, 2021 - spandidos-publications.com
Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease.
Studies have shown that exercise reduces kidney damage; however, the specific …

NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2. 5‑induced inflammation model

H Fukatsu, N Koide… - Molecular …, 2018 - spandidos-publications.com
PM2. 5 is a particle with a diameter< 2.5 µm that is often involved in air pollution.
Nanoparticles< 100 nm are thought to invade the trachea and lungs to cause inflammation …