Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual
neurons, taken out of their developmental context, readily form unspecific synapses. How …

Neuroscience research has evolved to generate increasingly large and complex
experimental data sets, and advanced data science tools are taking on central roles in …

Animal models play a pivotal role in translational neuroscience but recurrent problems in
data collection, analyses, and interpretation, lack of biomarkers, and a tendency to over …

Various specialized structural/functional properties are considered essential for contextual
memory encoding by hippocampal mossy fiber (MF) synapses. Although investigated to …

Diverse types of inhibitory interneurons (INs) impart computational power and flexibility to
neocortical circuits. Whereas markers for different IN types in cortical layers 2–6 (L2–L6) …

Commenting about science has risks. Being critical sometimes raises strong opposing
reactions. People work so hard and leaders do not like to see their strategies under fire …

A primary cilium is a membrane-bound extension from the cell surface that contains
receptors for perceiving and transmitting signals that modulate cell state and activity. Primary …

Background The study of the distinct structure and function of the human central nervous
system, both in healthy and diseased states, is becoming increasingly significant in the field …

X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease caused by a
retrotransposon insertion in intron 32 of the TAF1 gene. This insertion causes mis-splicing of …