HIV drug resistance in low-income and middle-income countries
After 15 years of global scale-up of antiretroviral therapy (ART), rising prevalence of HIV
drug resistance in many low-income and middle-income countries (LMICs) poses a growing …
drug resistance in many low-income and middle-income countries (LMICs) poses a growing …
Adherence, resistance, and viral suppression on dolutegravir in sub-Saharan Africa: implications for the TLD era
SM McCluskey, T Pepperrell, A Hill, WDF Venter… - Aids, 2021 - journals.lww.com
Dolutegravir (DTG) is now a component of preferred first-line antiretroviral therapy (ART)
worldwide. ADVANCE and NAMSAL were two landmark clinical trials conducted exclusively …
worldwide. ADVANCE and NAMSAL were two landmark clinical trials conducted exclusively …
Dolutegravir-based or low-dose efavirenz–based regimen for the treatment of HIV-1
NAMSAL ANRS 12313 Study … - New England Journal of …, 2019 - Mass Medical Soc
Background An efavirenz-based regimen (with a 600-mg dose of efavirenz, known as
EFV600) was the World Health Organization preferred first-line treatment for human …
EFV600) was the World Health Organization preferred first-line treatment for human …
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase
Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of
second generation integrase inhibitors. We sequenced pretreatment plasma specimens …
second generation integrase inhibitors. We sequenced pretreatment plasma specimens …
Curbing the rise of HIV drug resistance in low-income and middle-income countries: the role of dolutegravir-containing regimens
To improve virological suppression and address the emerging threat of HIV drug resistance,
many low-income and middle-income countries are moving away from non-nucleoside …
many low-income and middle-income countries are moving away from non-nucleoside …
Epidemiology of HIV drug resistance in low-and middle-income countries and WHO global strategy to monitor its emergence
S Bertagnolio, MR Jordan, A Giron… - Current Opinion in HIV …, 2022 - journals.lww.com
Epidemiology of HIV drug resistance in low- and middle-incom... : Current Opinion in HIV and
AIDS Epidemiology of HIV drug resistance in low- and middle-income countries and WHO …
AIDS Epidemiology of HIV drug resistance in low- and middle-income countries and WHO …
Low-abundance drug-resistant HIV-1 variants in antiretroviral drug-naive individuals: a systematic review of detection methods, prevalence, and clinical impact
Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …
High viral suppression and detection of dolutegravir-resistance associated mutations in treatment-experienced Tanzanian adults living with HIV-1 in Dar es Salaam
To curb HIV infection rate in Tanzania, antiretroviral therapy (ART) has been scaled up since
2006, and in 2019, the country shifted to regimen including dolutegravir as a default first line …
2006, and in 2019, the country shifted to regimen including dolutegravir as a default first line …
High-level dolutegravir resistance can emerge rapidly from few variants and spread by recombination: implications for integrase strand transfer inhibitor salvage …
K Huik, S Hill, J George, A Pau, S Kuriakose… - AIDS, 2022 - journals.lww.com
The integrase strand transfer inhibitor (INSTI) dolutegravir is commonly used in combination
antiretroviral therapy regimens and retains strong potency even with primary resistance …
antiretroviral therapy regimens and retains strong potency even with primary resistance …
Pre-treatment integrase inhibitor resistance and natural polymorphisms among HIV-1 subtype C infected patients in Ethiopia
DA Arimide, ZI Szojka, K Zealiyas, A Gebreegziabxier… - Viruses, 2022 - mdpi.com
Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …