Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …

Glioblastomas, like other solid tumors, have extensive areas of hypoxia and necrosis. The
importance of hypoxia in driving tumor growth is receiving increased attention. Hypoxia …

Purpose: Hypoxia is associated with resistance to radiotherapy and chemotherapy and
activates transcription factors that support cell survival and migration. We measured the …

Hypoxia is a significant feature of solid tumor cancers. Hypoxia leads to a more malignant
phenotype that is resistant to chemotherapy and radiation, is more invasive and has greater …

Highlights•Oncolytic adenoviruses (Onc. Ads) are promising as cancer gene therapy
agents.•Onc. Ad selectivity and cytolytic potency can be enhanced by genetic …

Oncolytic adenovirus (Ad) has been used in cancer gene therapy largely due to its ability to
selectively infect and replicate in tumor cells. However, because the oncolytic antitumor …

Abstract Purpose: Hypoxia inducible factor-1 (HIF-1), the central mediator of the cellular
response to low oxygen, functions as a transcription factor for a broad range of genes that …

Hypoxia develops in the majority of solid tumors due to the inability of the existing vascular
system to supply the growing tumor mass with adequate amounts of oxygen. A large body of …

Cancer propagating cells (CPCs) within primary central nervous system (CNS) tumors
(glioblastoma multiforme (GBM), medulloblastoma (MB) and ependymoma) might be …

Despite extensive research, current glioma therapies are still unsatisfactory, and novel
approaches are pressingly needed. In recent years, both nonreplicative viral vectors and …