Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …

Research in mammalian cell biology often relies on developing in vitro models to enable the
growth of cells in the laboratory to investigate a specific biological mechanism or process …

Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and
the microenvironment are key determinants of the multistep process of tumor development …

High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …

One of the obstacles limiting progress in the development of effective cancer therapies is the
shortage of preclinical models that capture the dynamic nature of tumor microenvironments …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis that
lacks targeted therapies, especially in patients with chemotherapy-resistant disease. Since …