Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …

Epigenetic silencing including histone modifications and DNA methylation is an important
tumorigenic mechanism. However, its role in cancer immunopathology and immunotherapy …

The gene encoding ARID1A, a chromatin remodeler, shows one of the highest mutation
rates across many cancer types. Notably, ARID1A is mutated in over 50% of ovarian clear …

Epigenetic regulators represent a promising new class of therapeutic targets for cancer.
Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2) …

SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

Abstract Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED
and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 …

Cellular senescence is an irreversible arrest of cell growth. Biochemical and morphological
changes occur during cellular senescence, including the formation of a unique cellular …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …