The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

The prevalence of immune-mediated disorders, including autoimmune conditions and
allergies, is steadily increasing. However, current therapeutic approaches are often non …

Extrahepatic nucleic acid delivery using polymers typically requires the synthesis and
purification of custom monomers, post-synthetic modifications, and incorporation of …

Polymeric nanoparticles (NPs) composed of poly (lactic-co-glycolic acid)(PLGA) have found
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …

Antigen-presenting cells (APCs) are widely studied for treating immune-mediated diseases,
and dendritic cells (DCs) are potent APCs that uptake and present antigens (Ags). However …

Allergic disease is a major global health concern that imposes significant life-altering and
economic burdens on affected individuals. However, there is still no cure. Polymer-based …

Immunogenicity affects the safety and efficacy of therapeutic proteins. This review is focused
on approaches for inducing immunological tolerance to circumvent the immunogenicity of …