DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm
in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic …

Malignant melanoma is the skin cancer with the most significant impact on man, carrying the
highest risk of death from metastasis. Both incidence and mortality rates continue to rise …

The analysis of genetic changes in primary cutaneous melanoma has been limited by the
need for fixation for diagnostic purposes. However, comparative genomic hybridization is …

MALT B cell lymphomas with t (1; 14)(p22; q32) showed a recurrent breakpoint upstream of
the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 …

Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …

CpG island methylation has been linked to tumor suppressor gene inactivation in neoplasia
and may serve as a useful marker to clone novel cancer-related genes. We have developed …