Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

The incidence of thyroid cancer and breast cancer is increasing year by year, and the
specific pathogenesis is unclear. Posttranslational modifications constitute an important …

Identification of branched-chain amino acid (BCAA) oxidation enzymes in the nucleus led us
to predict that they are a source of the propionyl-CoA that is utilized for histone …

Tricarboxylic acid (TCA) cycle, also called Krebs cycle or citric acid cycle, is an amphoteric
pathway, contributing to catabolic degradation and anaplerotic reactions to supply …

Metabolism regulates cardiovascular biology through multiple mechanisms, including
epigenetic modifications. Over the past two decades, experimental and preclinical studies …

Regulation of mitochondrial structure and function is a central component of infection with
viruses, including human cytomegalovirus (HCMV), as a virus means to modulate cellular …

Eukaryotes must balance the metabolic and cell death actions of mitochondria via control of
gene expression and cell fate by chromatin, thereby functionally binding the metabolome …

Objective We previously reported that β-oxidation enzymes are present in the nucleus in
close proximity to transcriptionally active promoters. Thus, we hypothesized that the fatty …

Dihydrolipoamide dehydrogenase (DLD) deficiency is a recessive mitochondrial disorder
caused by depletion of DLD from α-ketoacid dehydrogenase complexes. Caenorhabditis …

Bone formation and homeostasis are controlled by environmental factors and endocrine
regulatory cues that initiate intracellular signaling pathways capable of modulating gene …