Mitochondrial electron transport chain, ROS generation and uncoupling
RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …
well as the electron transporters ubiquinone and cytochrome c. There are two electron …
Reactive oxygen species induced pathways in heart failure pathogenesis and potential therapeutic strategies
A Mongirdienė, L Skrodenis, L Varoneckaitė… - Biomedicines, 2022 - mdpi.com
With respect to structural and functional cardiac disorders, heart failure (HF) is divided into
HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) …
HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) …
Right ventricular heart failure from pulmonary embolism: key distinctions from chronic pulmonary hypertension
JA Watts, MR Marchick, JA Kline - Journal of cardiac failure, 2010 - Elsevier
BACKGROUND: The right ventricle normally operates as a low pressure, high-flow pump
connected to a high-capacitance pulmonary vascular circuit. Morbidity and mortality in …
connected to a high-capacitance pulmonary vascular circuit. Morbidity and mortality in …
Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G
The second messenger cyclic guanosine 3′ 5′ monophosphate (cGMP) and its
downstream effector protein kinase G (PKG) have been discovered more than 40 years ago …
downstream effector protein kinase G (PKG) have been discovered more than 40 years ago …
Right heart in pulmonary hypertension: from adaptation to failure
X Ren, RA Johns, WD Gao - Pulmonary circulation, 2019 - journals.sagepub.com
Right ventricular (RV) failure (RVF) has garnered significant attention in recent years
because of its negative impact on clinical outcomes in patients with pulmonary hypertension …
because of its negative impact on clinical outcomes in patients with pulmonary hypertension …
Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS …
Mitochondria represent major sources of basal reactive oxygen species (ROS) production of
the cardiomyocyte. The role of ROS as signaling molecules that mediate different …
the cardiomyocyte. The role of ROS as signaling molecules that mediate different …
Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle
Rationale: One of the physiological mechanisms by which the heart adapts to a rise in blood
pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a …
pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a …
Signaling pathways concerning mitochondrial dysfunction: implications in neurodegeneration and possible molecular targets
Mitochondrion is an important organelle present in our cells responsible for meeting energy
requirements. All higher organisms rely on efficient mitochondrial bioenergetic machinery to …
requirements. All higher organisms rely on efficient mitochondrial bioenergetic machinery to …
Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3
N Wang, HH Xu, W Zhou, H Yang, J Wang, Z Ma… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Aconite is a processed product of seminal root of
perennial herbaceous plant Aconitum Carmichaclii Debx. of Ranunculaceae. It has the …
perennial herbaceous plant Aconitum Carmichaclii Debx. of Ranunculaceae. It has the …