Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary
sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to …

The family of vascular endothelial growth factors (VEGFs) includes 5 members (VEGF-A to-
D, and placenta growth factor), which regulate several critical biological processes. VEGF-A …

Renal fibrosis induced by urinary tract obstruction is a common clinical occurrence;
however, effective treatment is lacking, and a deeper understanding of the mechanism of …

Methods: We studied humans with primary biliary cholangitis (PBC) and Primary sclerosing
cholangitis (PSC), P4HA2-/-mice injured by DDC, and P4HA2-/-/MDR2-/-double knockout …

Polycystic ovary syndrome (PCOS) affects approximately 15% of women of reproductive age
worldwide. It is the most prevalent endocrine disorder with marked risks for female infertility …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the
seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model …

Fibrotic alterations resulting from abnormal tissue repair after lung injury are responsible for
the high mortality observed after acute respiratory distress syndrome. Therefore, the …

Matrix stiffness is a central modulator of hepatic stellate cells (HSCs) activation and hepatic
fibrogenesis. However, the long non-coding RNAs (lncRNAs)-regulated transcriptional …

Abstract Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in
epithelial tissues and frequently associates with integrin subunit αv to form transmembrane …

Cardiac fibrosis under chronic pressure overload is an end-stage adverse remodeling of
heart. However, current heart failure treatments barely focus on anti-fibrosis and the effects …