Roles of transposable elements in the regulation of mammalian transcription

R Fueyo, J Judd, C Feschotte, J Wysocka - Nature reviews Molecular …, 2022 - nature.com
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Transposable elements shape the evolution of mammalian development

AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Ten things you should know about transposable elements

G Bourque, KH Burns, M Gehring, V Gorbunova… - Genome biology, 2018 - Springer
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

Regulatory activities of transposable elements: from conflicts to benefits

EB Chuong, NC Elde, C Feschotte - Nature Reviews Genetics, 2017 - nature.com
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

Inflammation and DNA damage: cause, effect or both

A Pezone, F Olivieri, MV Napoli, A Procopio… - Nature Reviews …, 2023 - nature.com
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

Placenta: the forgotten organ

E Maltepe, SJ Fisher - Annual review of cell and developmental …, 2015 - annualreviews.org
The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents

SF Gilbert, TCG Bosch, C Ledón-Rettig - Nature Reviews Genetics, 2015 - nature.com
The integration of research from developmental biology and ecology into evolutionary theory
has given rise to a relatively new field, ecological evolutionary developmental biology (Eco …

Mammalian transposable elements and their impacts on genome evolution

RN Platt, MW Vandewege, DA Ray - Chromosome Research, 2018 - Springer
Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …

Mammalian evolution of human cis-regulatory elements and transcription factor binding sites

G Andrews, K Fan, HE Pratt, N Phalke… - Science, 2023 - science.org
Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …

Fertile ground: human endometrial programming and lessons in health and disease

J Evans, LA Salamonsen, A Winship… - Nature Reviews …, 2016 - nature.com
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired,
regenerated and remodelled, primarily under the orchestration of oestrogen and …