Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Transposable elements shape the evolution of mammalian development
AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Ten things you should know about transposable elements
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …
extent of their impact on genome evolution, function, and disease remain a matter of intense …
Regulatory activities of transposable elements: from conflicts to benefits
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
Placenta: the forgotten organ
E Maltepe, SJ Fisher - Annual review of cell and developmental …, 2015 - annualreviews.org
The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …
mediates nutrient and waste exchange to enable in utero existence. Placental cells …
Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents
The integration of research from developmental biology and ecology into evolutionary theory
has given rise to a relatively new field, ecological evolutionary developmental biology (Eco …
has given rise to a relatively new field, ecological evolutionary developmental biology (Eco …
Mammalian transposable elements and their impacts on genome evolution
Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
Fertile ground: human endometrial programming and lessons in health and disease
J Evans, LA Salamonsen, A Winship… - Nature Reviews …, 2016 - nature.com
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired,
regenerated and remodelled, primarily under the orchestration of oestrogen and …
regenerated and remodelled, primarily under the orchestration of oestrogen and …