The role of the host extracellular matrix (ECM) in infection tends to be neglected. However,
the complex interactions between invading pathogens, host tissues and immune cells occur …

Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …

Lyme disease, caused by Borrelia burgdorferi, B. afzelii and B. garinii, is a chronic, multi-
systemic infection and the spectrum of tissues affected can vary with the Lyme disease …

Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host
innate immune system, including the complement cascade. The Lyme disease spirochete …

The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto,
termed BBK32-C, binds and inhibits the initiating serine protease of the human classical …

Summary Myalgic Encephalomyelitis/Chronic Fatigue syndrome (ME/CFS) is a complex,
debilitating, long-term illness without a diagnostic biomarker. ME/CFS patients share …

In most patients with Lyme arthritis (LA), antibiotic therapy results in Borrelia burgdorferi
pathogen elimination, tissue repair, and return to homeostasis. However, despite spirochetal …

Extracellular matrix stiffness (ECM) is one of the many mechanical forces acting on
mammalian adherent cells and an important determinant of cellular function. While the effect …

ABSTRACT The Lyme disease spirochete Borrelia burgdorferi sensu lato can cause a
multitude of clinical manifestations because of its ability to disseminate into any organ …

Lyme disease, caused by infection with pathogenic Borrelia bacteria, has emerged as a
pervasive illness throughout North America and many other regions of the world in recent …