The characterization of the molecular mechanisms involved in development and
progression of melanoma could be helpful to identify the molecular profiles underlying …

Abstract Since the mid-1950's, melanoma incidence has been rising steadily in
industrialized Caucasian populations, thereby pointing to the pivotal involvement of …

The tumor suppressor p53 is activated in response to cellular stress to prevent malignant
transformation by activation of the DNA repair machinery to preserve the cell, or by induction …

Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma,
rhabdomyosarcoma, and melanoma) were continuously exposed to increasing …

Molecular mechanisms involved in pathogenesis of malignant melanoma have been widely
studied and novel therapeutic treatments developed in recent past years. Molecular targets …

The term barrier function as applied to human skin often connotes the physical properties of
this organ that provides protection from its surrounding environment. This term does not …

Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and
dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in …

Plants are a rich source of secondary metabolites that exhibit numerous desired properties.
The compounds may influence the biology of melanocytes, pigment cells that produce …

The development of complex stratified epithelial barriers in mammals is initiated from single-
layered epithelia. How stratification is initiated and fueled are still open questions. Previous …

Resveratrol, a naturally occurring polyphenol, has been reported to be an anti-tumor and
chemopreventive agent. Recent data show that it may also exert anti-angiogenic effects. We …