A comprehensive review on thiazole based conjugates as anti-cancer agents
Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …
Current scenario of chalcone hybrids with antibreast cancer therapeutic applications
H Wang, J Zhu, Q Zhang, J Tang… - Archiv der …, 2024 - Wiley Online Library
Breast cancer, an epithelial malignant tumor that occurs in the terminal ducts of the breast, is
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …
Design, synthesis, and biological evaluation studies of novel naphthalene-chalcone hybrids as antimicrobial, anticandidal, anticancer, and VEGFR-2 inhibitors
D Osmaniye, BN Sağlık, N Khalilova, S Levent… - ACS …, 2023 - ACS Publications
Cancer is a progressive disease that is frequently encountered worldwide. The incidence of
cancer is increasing with the changing living conditions around the world. The side-effect …
cancer is increasing with the changing living conditions around the world. The side-effect …
Synthesis, spectroscopic characterization, antibacterial activity, and computational studies of novel pyridazinone derivatives
In this work, a novel series of pyridazinone derivatives (3–17) were synthesized and
characterized by NMR (1H and 13C), FT-IR spectroscopies, and ESI-MS methods. All …
characterized by NMR (1H and 13C), FT-IR spectroscopies, and ESI-MS methods. All …
Pyridazinones containing the (4-methoxyphenyl) piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation
Alzheimer's disease is a progressive and fatal neurodegenerative disease affecting the
elderly population accompanied by a decrease in cholinergic transmission, impairing …
elderly population accompanied by a decrease in cholinergic transmission, impairing …
Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy framework, docking and molecular dynamic simulations of (E)-4-(4-methylbenzyl)-6-styrylpyridazin …
In this work, a novel crystal,(E)-4-(4-methylbenzyl)-6-styrylpyridazin-3 (2H)-one (E-BSP) was
synthesized via Knoevenagel condensation of benzaldehyde and (E)-6-(4-methoxystyryl)-4 …
synthesized via Knoevenagel condensation of benzaldehyde and (E)-6-(4-methoxystyryl)-4 …
The impact of halogen substitution on the corrosion inhibition of imidazothiazole derivatives for mild steel in corrosive media (Part A)
Our research aims to investigate the impact of halogens on the effectiveness of corrosion
inhibitors for mild steel in a 1 M HCl solution, employing a holistic approach. Through …
inhibitors for mild steel in a 1 M HCl solution, employing a holistic approach. Through …
Visible Light-Prompted Regioselective Synthesis of Novel 5-Aroyl/hetaroyl-2′, 4-dimethyl-2, 4′-bithiazoles as DNA-and BSA-Targeting Agents
R Aggarwal, N Jain, GP Dubey, S Singh… - …, 2023 - ACS Publications
Organic transformations mediated by visible light have gained popularity in recent years as
they are green, renewable, inexpensive, and clean and yield excellent products. The …
they are green, renewable, inexpensive, and clean and yield excellent products. The …
Chalcone-based imidazo[2,1-b]thiazole derivatives: synthesis, crystal structure, potent anticancer activity, and computational studies
In this work, two novel chalcone-based imidazothiazole derivatives ITC-1 and ITC-2 were
synthesized and characterized by 1H NMR, 13C NMR and high-resolution mass …
synthesized and characterized by 1H NMR, 13C NMR and high-resolution mass …
Design, synthesis and in silico molecular docking evaluation of novel 1, 2, 3-triazole derivatives as potent antimicrobial agents
SR Baddam, MK Avula, R Akula, VR Battula… - Heliyon, 2024 - cell.com
Chalcone and triazole scaffolds have demonstrated a crucial role in the advancement of
science and technology. Due to their significance, research has proceeded on the design …
science and technology. Due to their significance, research has proceeded on the design …