Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

The fundamental importance of prefrontal cortical connectivity to information processing and,
therefore, disorders of cognition, emotion, and behavior has been recognized for decades …

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Connections among brain regions allow pathological perturbations to spread from a single
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …

The hypothesis that pathogenic protein aggregates associated with neurodegenerative
diseases spread from cell-to-cell in the brain in a manner akin to infectious prions has …

Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in
structural connectivity in neurodegeneration. Here, we investigated the longitudinal …

Mounting evidence shows that Alzheimer's disease (AD) is characterized by the propagation
of tau aggregates throughout the brain in a prion-like manner. Since current pathology …

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Neuroimaging is increasingly being included in clinical trials of Huntington's disease (HD)
for a wide range of purposes from participant selection and safety monitoring, through to …

Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of
CAG trinucleotide repeat located in the exon 1 of Huntingtin (HTT) gene in human …