Associations between cells and the basement membrane are critical for a variety of
biological events including cell proliferation, cell migration, cell differentiation and the …

The post-translational glycosylation of select proteins by O-linked mannose (O-mannose or
O-man) is a conserved modification from yeast to humans and has been shown to be …

Abstract α-Dystroglycan (α-DG) is uniquely modified on O-mannose sites by a repeating
disaccharide (-Xylα1, 3-GlcAβ1, 3-) n termed matriglycan, which is a receptor for laminin-G …

α-Neurexins (α-Nrxn) are mostly presynaptic cell surface molecules essential for
neurotransmission that are linked to neuro-developmental disorders as autism or …

The mammalian O-mannosylation pathway for protein post-translational modification is
intricately involved in modulating cell–matrix interactions in the musculature and nervous …

Glycosylation is a crucial posttranslational modification that is involved in numerous
biological events. Therefore, abnormal glycosylation can impair the functions of …

Mutations in multiple genes required for proper O-mannosylation of α-dystroglycan are
causal for congenital/limb-girdle muscular dystrophies and abnormal brain development in …

Dystroglycanopathy is a major class of congenital muscular dystrophy that is caused by a
deficiency of functional glycans on α-dystroglycan (α-DG) with laminin-binding activity. A …

Human natural killer-1 (HNK-1) carbohydrate (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-R) is highly
expressed in the brain and required for learning and neural plasticity. We previously …

Dystroglycanopathies form a subgroup of muscular dystrophies that arise from defects in
enzymes that are implicated in the recently elucidated O‐mannosylation pathway, thereby …