Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with
multiple and outstanding cell biological functions. The history of their structural analysis …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Cell surfaces in the immune system are richly equipped with a complex mixture of glycans,
which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of …

The glycan chains of vertebrate glycoconjugates are composed mostly of five-and six-
carbon sugars. One striking exception is the family of sialic acids (Sia), which are R-keto …

Sialic acid–binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid–
containing ligands and are mainly expressed by cells of the immune system. Many Siglecs …

Sialic acids are one of the most important molecules of life, since they occupy the terminal
position on macromolecules and cell membranes and are involved in many biological and …