Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …

Cardiovascular diseases represent the major cause of morbidity and mortality worldwide.
Multiple studies have been conducted so far in order to develop treatments able to prevent …

Direct cellular reprogramming provides a powerful platform to study cell plasticity and
dissect mechanisms underlying cell fate determination. Here, we report a single-cell …

Background The conversion of fibroblasts into induced cardiomyocytes may regenerate
myocardial tissue from cardiac scar through in situ cell transdifferentiation. The efficiency …

Cardiovascular disease is the leading cause of death worldwide, outpacing pulmonary
disease, infectious disease, and all forms of cancer. Myocardial infarction (MI) dominates …

Cell reprogramming is a groundbreaking technology that, in few decades, generated a new
paradigm in biomedical science. To date we can use cell reprogramming to potentially …

Translation of upstream open reading frames (uORFs) typically abrogates translation of
main (m) ORFs. The molecular mechanism of uORF regulation in cells is not well …

Introduction Somatic cell fate transition is now gained great importance in tissue
regeneration. Currently, research is focused on heart tissue regeneration by reprogramming …

Background Given known inefficiencies in reprogramming of fibroblasts into mature induced
cardiomyocytes (iCM s), we sought to identify small molecules that would overcome these …

Cardiovascular diseases are a common cause of death worldwide. Adult cardiomyocytes
have limited regenerative capacity after injury, and there is growing interest in cardiac …