Abstract The Allen Brain Atlas, a Web-based, genome-wide atlas of gene expression in the
adult mouse brain, was an experiment on a massive scale. The development of the atlas …

How any complex trait has evolved is a fascinating question, yet the evolution of parasitism
among the nematodes is arguably one of the most arresting. How did free-living nematodes …

The C. elegans genome has been completely sequenced, and the developmental anatomy
of this model organism is described at single-cell resolution. Here we utilize strategies that …

Polymodal nociceptors detect noxious stimuli, including harsh touch, toxic chemicals and
extremes of heat and cold. The molecular mechanisms by which nociceptors are able to …

Ageing is a complex process with common and distinct features across tissues. Unveiling
the underlying processes driving ageing in individual tissues is indispensable to decipher …

Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-
evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe …

Cholinergic motor neurons are defined by the coexpression of a battery of genes encoding
proteins that act sequentially to synthesize, package and degrade acetylcholine and …

We revisit the classification of neuronal cell types in the nervous system of the nematode
Caenorhabditis elegans. Based on anatomy and synaptic connectivity patterns, the 302 …

In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a
robust extension in lifespan, improved late life health, and protection from age-related …

The dorsal and ventral regions of the hippocampus are important in cognitive and emotional
processing, respectively. Various approaches have revealed the differential molecular and …