Unlocking the Epigenetic Symphony: Histone Acetylation Orchestration in Bone Remodeling and Diseases
Histone acetylation orchestrates a complex symphony of gene expression that controls
cellular fate and activities, including the intricate processes of bone remodeling. Despite its …
cellular fate and activities, including the intricate processes of bone remodeling. Despite its …
Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming
Profound functional switch of key regulatory factors may play a major role in homeostasis
and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with …
and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with …
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis
AK Hauck, R Mehmood, BJ Carpenter… - Nature …, 2024 - nature.com
Nuclear receptor corepressors (NCoRs) function in multiprotein complexes containing
histone deacetylase 3 (HDAC3) to alter transcriptional output primarily through repressive …
histone deacetylase 3 (HDAC3) to alter transcriptional output primarily through repressive …
Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts
In this issue, Abe et al 1 report a novel mechanism by which RANKL stimulates osteoclast
differentiation and bone resorption through non-coding RNAs that bind PGC-1β and convert …
differentiation and bone resorption through non-coding RNAs that bind PGC-1β and convert …
Cooperativity among clustered κB sites within promoters and enhancers dictates transcriptional specificity of NF-κB RelA along with specific cofactors
S Shahabi, T Biswas, Y Shen, Y Zou, R Sanahmadi… - bioRxiv, 2024 - biorxiv.org
The functional role of weak DNA binding sites for transcription factor (TF) recruitment and
gene expression remains largely unknown. Our study reveals that the weak NF-κB DNA …
gene expression remains largely unknown. Our study reveals that the weak NF-κB DNA …
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
AM Elmansi, A Kassem, RM Castilla, RA Miller - GeroScience, 2024 - Springer
Many aspects of inflammation increase with aging in mice and humans. Transcriptomic
analysis revealed that many murine anti-aging interventions produce lower levels of pro …
analysis revealed that many murine anti-aging interventions produce lower levels of pro …
The methyltransferase MLL4 promotes nonalcoholic steatohepatitis by enhancing NF-κB signaling
J Lee, H An, CS Kim, S Lee - Journal of Biological Chemistry, 2024 - jbc.org
Non-alcoholic fatty liver disease (NAFLD) is a growing health problem worldwide, ranging
from non-alcoholic fatty liver (NAFL) to the more severe metabolic non-alcoholic …
from non-alcoholic fatty liver (NAFL) to the more severe metabolic non-alcoholic …
A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation
The nuclear receptor corepressor (NCoR) forms a complex with histone deacetylase 3
(HDAC3) that mediates repressive functions of unliganded nuclear receptors and other …
(HDAC3) that mediates repressive functions of unliganded nuclear receptors and other …