The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the
fundamental life processes they represent, but also because meiosis involves the formation …

▪ Abstract The separation of sister chromatids at the metaphase to anaphase transition is
one of the most dramatic of all cellular events and is a crucial aspect of all sexual and …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

▪ Abstract Protein complexes consisting of s tructural m aintenance of c hromosomes (SMC)
and kleisin subunits are crucial for the faithful segregation of chromosomes during cell …

In eukaryotes, sister chromatids remain connected from the time of their synthesis until they
are separated in anaphase. This cohesion depends on a complex of proteins called …

The separation of sister chromatids in anaphase depends on the dissociation of cohesin
from chromosomes. In vertebrates, some cohesin is removed from chromosomes at the …

Meiosis is the type of cell division that gives rise to eggs and sperm. Errors in the execution
of this process can result in the generation of aneuploid gametes, which are associated with …

Sister chromatid cohesion is mediated by evolutionary conserved chromosomal proteins,
termed" cohesins." Using an extension of chromatin immunoprecipitation, we have analyzed …