Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Transition-metal-catalyzed reactions have been studied since the very beginning of the past
century and represent a great success in organic chemistry, along with the birth and growth …

1. INTRODUCTION Within 14 years of the seminal experiments of JD Roberts leading to the
first proposal of the structure of benzyne (1), 1 synthetic organic chemists recognized the …

This tutorial review is aimed at highlighting recent developments in transition-metal-free
carbon–carbon and carbon–heteroatom bond-forming reactions utilizing a versatile class of …

About two decades after Kobayashi's discovery in 1983 of a very mild way of generating
highly reactive aryne intermediates, the synthetic community embraced o-(trimethylsilyl) aryl …

The synthesis of biaryls from benzyne intermediates offers an alternative strategy to
conventional metal-catalyzed cross-coupling approaches. The concept is as old as benzyne …

The pyridine heterocycle continues to play a vital role in the development of human
medicines. More than 100 currently marketed drugs contain this privileged unit, which …

Arynes are neutral intermediates in which two adjacent atoms of an aromatic ring lack
substituents, thus leaving two atomic orbitals (perpendicular to the aromatic x system) to …

An efficient, transition-metal-free procedure for the N-arylation of amines, sulfonamides, and
carbamates and O-arylation of phenols and carboxylic acids has been achieved by allowing …

Heterocycles containing N and O are important structures in pharmaceuticals,
agrochemicals and functional molecules. The synthesis of these compounds usually …