Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …

Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …

Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …

Abstract Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain.
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …

The ubiquitous secondary messengers, Ca 2+ and cAMP, play a vital role in shaping a
diverse array of physiological processes. More significantly, accumulating evidence over the …

This review discusses the driving principles that may underlie neurodegeneration in
dementia, represented most dominantly by Alzheimer's disease (AD). While a myriad of …

The theory that aging is driven by the damage produced by reactive oxygen species (ROS)
derived from oxidative metabolism dominated geroscience studies during the second half of …

A primary reason behind the high level of complexity we embody as multicellular organisms
is a highly complex intracellular and intercellular communication system. As a result, the …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …

Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced
Ca2+ release in response to activity-generated Ca2+ influx play a significant role in …