VEGF-A in cardiomyocytes and heart diseases
M Braile, S Marcella, L Cristinziano… - International Journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …
Cardiac myosin contraction and mechanotransduction in health and disease
SK Barrick, MJ Greenberg - Journal of Biological Chemistry, 2021 - ASBMB
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force
Contraction in striated muscle is initiated by calcium binding to troponin complexes, but it is
now understood that dynamic transition of myosin between resting, ordered OFF states on …
now understood that dynamic transition of myosin between resting, ordered OFF states on …
Small angle X-ray diffraction as a tool for structural characterization of muscle disease
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …
structural information from striated muscle fibers under hydrated physiological conditions …
The sliding filament theory since Andrew Huxley: multiscale and multidisciplinary muscle research
Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …
muscle contraction based on force-generating interactions between myofilaments in the …
Danicamtiv increases myosin recruitment and alters cross-bridge cycling in cardiac muscle
BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …
Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure
2'-deoxy-ATP (dATP) improves cardiac function by increasing the rate of crossbridge cycling
and Ca 2+ transient decay. However, the mechanisms of these effects and how therapeutic …
and Ca 2+ transient decay. However, the mechanisms of these effects and how therapeutic …
The biochemically defined super relaxed state of myosin—a paradox
The biochemical SRX (super-relaxed) state of myosin has been defined as a low ATPase
activity state. This state can conserve energy when the myosin is not recruited for muscle …
activity state. This state can conserve energy when the myosin is not recruited for muscle …
Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation
Muscle contraction is performed by arrays of contractile proteins in the sarcomere. Serious
heart diseases, such as cardiomyopathy, can often be results of mutations in myosin and …
heart diseases, such as cardiomyopathy, can often be results of mutations in myosin and …
Mitochondrial transplantation ameliorates doxorubicin-induced cardiac dysfunction via activating glutamine metabolism
X Sun, H Chen, R Gao, Y Huang, Y Qu, H Yang, X Wei… - Iscience, 2023 - cell.com
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also
related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to …
related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to …