Non-invasive drug delivery across the blood–brain barrier: a prospective analysis

SK Niazi - Pharmaceutics, 2023 - mdpi.com
Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant
advancement in treating neurological diseases. The BBB is a tightly packed layer of …

Niosomes for nose-to-brain delivery: a non-invasive versatile carrier system for drug delivery in neurodegenerative diseases

AR Al Jayoush, HAFM Hassan, H Asiri, M Jafar… - Journal of Drug Delivery …, 2023 - Elsevier
Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

[HTML][HTML] Access to the CNS: Strategies to overcome the BBB

B Sánchez-Dengra, I González-Álvarez… - International Journal of …, 2023 - Elsevier
The blood–brain barrier (BBB) limits the access of substances to the central nervous system
(CNS) which hinders the treatment of pathologies affecting the brain and the spinal cord …

Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology

FM Pramotton, S Spitz, RD Kamm - Advanced Science, 2024 - Wiley Online Library
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Neuroprotective peptides and new strategies for ischemic stroke drug discoveries

LV Dergunova, IB Filippenkov, SA Limborska… - Genes, 2023 - mdpi.com
Ischemic stroke continues to be one of the leading causes of death and disability in the adult
population worldwide. The currently used pharmacological methods for the treatment of …

Advancements in the Application of Nanomedicine in Alzheimer's Disease: A Therapeutic Perspective

N Puranik, D Yadav, M Song - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects most
people worldwide. AD is a complex central nervous system disorder. Several drugs have …

Advances in nanotherapeutic strategies for Huntington's disease: Design, delivery, and neuroprotective mechanisms

S Khan, N Bano, S Ahamad, NJ Dar, A Nazir… - Coordination Chemistry …, 2025 - Elsevier
Huntington's Disease (HD) is a severe neurodegenerative disorder lacking effective
diagnostic and treatment options. However, there is increasing interest in the potential of …

Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation

I Mármol, S Abizanda-Campo, JM Ayuso, I Ochoa… - Bioengineering, 2023 - mdpi.com
Current available animal and in vitro cell-based models for studying brain-related
pathologies and drug evaluation face several limitations since they are unable to reproduce …

Nanomaterial-Based Strategies for Attenuating T-Cell-Mediated Immunodepression in Stroke Patients: Advancing Research Perspectives

Y Wang, C Liu, Y Ren, J Song, K Fan… - International Journal …, 2024 - Taylor & Francis
This review article discusses the potential of nanomaterials in targeted therapy and
immunomodulation for stroke-induced immunosuppression. Although nanomaterials have …

Progress of nanoparticle drug delivery system for the treatment of glioma

G Lai, H Wu, K Yang, K Hu, Y Zhou, X Chen… - … in Bioengineering and …, 2024 - frontiersin.org
Gliomas are typical malignant brain tumours affecting a wide population worldwide.
Operation, as the common treatment for gliomas, is always accompanied by postoperative …