p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

A. Single-transmembrane segment receptors B. Seven-transmembrane receptors C. Steroid
hormones D. Intracellular second messengers IV. Cyclins and CKIs in Endocrine Tumors A …

The hormonal form of vitamin D, 1, 25-dihydroxyvitamin D3, acting through its cognate
nuclear receptor (vitamin D3 receptor, VDR) will induce myeloid leukemic cell lines to …

We have used a sensitive and reproducible method of measuring mRNA expression to
compare basal levels of 10 transcripts in the 60 cell lines of the National Cancer Institute's in …

p63 is a recently identified homolog of p53 that is found in the basal layer of several stratified
epithelial tissues such as the epidermis, oral mucosa, prostate, and urogenital tract. Studies …

Much of the predisposition to hereditary breast and ovarian cancer has been attributed to
inherited defects in the BRCA1 tumour-suppressor gene,,. The nuclear protein BRCA1 has …

The peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription
factor belonging to the steroid receptor superfamily. It is a key regulator of adipogenic …

Histone acetylation is emerging as a major regulatory mechanism thought to modulate gene
expression by altering the accessibility of transcription factors to DNA. In this study, treatment …

The p21 protein is found in the nucleus of most cells at low levels and is induced to elevated
levels after DNA damage, causing cell-cycle arrest. We have reported that p21 mRNA is …

Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although
seemingly discrete and unrelated mechanisms, these pathways can now be shown to be …