[HTML][HTML] Chemical modifications to increase the therapeutic potential of antimicrobial peptides

Y Han, M Zhang, R Lai, Z Zhang - Peptides, 2021 - Elsevier
The continued use of antibiotics has been accompanied by the rapid emergence and spread
of antibiotic-resistant strains of bacteria. Antimicrobial peptides (AMPs), also known as host …

Computational methods and tools in antimicrobial peptide research

PGA Aronica, LM Reid, N Desai, J Li… - Journal of Chemical …, 2021 - ACS Publications
The evolution of antibiotic-resistant bacteria is an ongoing and troubling development that
has increased the number of diseases and infections that risk going untreated. There is an …

Antimicrobial susceptibility testing of antimicrobial peptides to better predict efficacy

DK Mercer, MDT Torres, SS Duay, E Lovie… - Frontiers in cellular …, 2020 - frontiersin.org
During the development of antimicrobial peptides (AMP) as potential therapeutics,
antimicrobial susceptibility testing (AST) stands as an essential part of the process in …

Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a (1-21) NH2 as a reliable strategy for antipseudomonal drugs

B Casciaro, M Moros, S Rivera-Fernandez, A Bellelli… - Acta biomaterialia, 2017 - Elsevier
Naturally occurring antimicrobial peptides (AMPs) hold promise as future therapeutics
against multidrug resistant microorganisms. Recently, we have discovered that a derivative …

Antimicrobial peptides: promising compounds against pathogenic microorganisms

J Cruz, C Ortiz, F Guzman… - Current medicinal …, 2014 - ingentaconnect.com
In the last decades, the indiscriminate use of conventional antibiotics has generated high
rates of microbial resistance. This situation has increased the need for obtaining new …

Sonorensin: a new bacteriocin with potential of an anti-biofilm agent and a food biopreservative

L Chopra, G Singh, K Kumar Jena, DK Sahoo - Scientific reports, 2015 - nature.com
The emergence of antibiotic resistant bacteria has led to exploration of alternative
therapeutic agents such as ribosomally synthesized bacterial peptides known as …

[PDF][PDF] Antimicrobial peptides from frog skin: biodiversity and therapeutic promises

A Ladram, P Nicolas - Front. Biosci, 2016 - article.imrpress.com
More than a thousand antimicrobial peptides (AMPs) have been reported in the last decades
arising from the skin secretion of amphibian species. Generally, each frog species can …

Lipidated analogs of the LL-37-derived peptide fragment KR12—structural analysis, surface-active properties and antimicrobial activity

E Kamysz, E Sikorska, M Jaśkiewicz, M Bauer… - International journal of …, 2020 - mdpi.com
An increasing number of multidrug-resistant pathogens is a serious problem of modern
medicine and new antibiotics are highly demanded. In this study, different n-alkyl acids (C2 …

Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria

S Bhattacharjya, SK Straus - International Journal of Molecular Sciences, 2020 - mdpi.com
In an era where the pipeline of new antibiotic development is drying up, the continuous rise
of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine …

Rational Design of Phe‐BODIPY Amino Acids as Fluorogenic Building Blocks for Peptide‐Based Detection of Urinary Tract Candida Infections

L Mendive‐Tapia, D Mendive‐Tapia… - Angewandte Chemie …, 2022 - Wiley Online Library
Fungal infections caused by Candida species are among the most prevalent in hospitalized
patients. However, current methods for the detection of Candida fungal cells in clinical …