The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of
vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon …

Bacterial microcompartments are organelles composed of a protein shell that surrounds
functionally related proteins. Bioinformatic analysis of sequenced genomes indicates that …

The article reviews the significant contributions to, and the present status of, applications of
computational methods for the characterization and prediction of protein–carbohydrate …

Sialic acids have a pivotal functional impact in many biological interactions such as virus
attachment, cellular adhesion, regulation of proliferation, and apoptosis. A common …

Capsular polysaccharides are important virulence factors in pathogenic bacteria.
Characterizing the structural components and biosynthetic pathways for these …

Abnormal glycosylation is a common feature in disease that typically results from
misregulation in expression and/or activity of glycosyltransferases (GTs) and glycosidases …

N-Acetylneuraminate lyases (NALs) or sialic acid aldolases catalyze the reversible aldol
cleavage of N-acetylneuraminic acid (Neu5Ac, the most common form of sialic acid) to form …

Polysaccharides represent essential, although highly structurally diverse, components on
microbial cell surfaces. They are the primary interface with the host and play critical roles in …

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia
and responsible for severe economic losses worldwide. The capsule polymer of App …