Clinical pharmacology of antibiotics

RF Eyler, K Shvets - Clinical Journal of the American Society of …, 2019 - journals.lww.com
Antimicrobial pharmacology and its effect on prescribing is quite complex. Selecting an
antibiotic that will optimally treat an infection while minimizing adverse effects and the …

Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children—a meta-analysis

JF Roos, J Doust, SE Tett, CMJ Kirkpatrick - Clinical biochemistry, 2007 - Elsevier
OBJECTIVES:: To perform a systematic review comparing the diagnostic accuracy of CysC
with SCr. METHODS:: MEDLINE and EMBASE (January 1984–February 2006) were …

[HTML][HTML] Drug dosing consideration in patients with acute and chronic kidney disease—a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)

GR Matzke, GR Aronoff, AJ Atkinson Jr, WM Bennett… - Kidney international, 2011 - Elsevier
Drug dosage adjustment for patients with acute or chronic kidney disease is an accepted
standard of practice. The challenge is how to accurately estimate a patient's kidney function …

Pharmacokinetics and dosage adjustment in patients with renal dysfunction

RK Verbeeck, FT Musuamba - European journal of clinical pharmacology, 2009 - Springer
Introduction Chronic kidney disease is a common, progressive illness that is becoming a
global public health problem. In patients with kidney dysfunction, the renal excretion of …

Effect of cobicistat on glomerular filtration rate in subjects with normal and impaired renal function

P German, HC Liu, J Szwarcberg… - JAIDS Journal of …, 2012 - journals.lww.com
Objective: This study evaluated the effect of cobicistat (COBI) on glomerular filtration rate in
subjects with normal renal function (RF) or with mild/moderate renal impairment, by …

[HTML][HTML] Implications of augmented renal clearance in critically ill patients

AA Udy, JA Roberts, J Lipman - Nature Reviews Nephrology, 2011 - nature.com
Critically ill patients can display markedly abnormal physiological parameters compared
with those in ward-based or ambulatory settings. As a function of both the underlying …

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

FY Bois, M Jamei, HJ Clewell - Toxicology, 2010 - Elsevier
Generic PBPK models, applicable to a large number of substances, coupled to parameter
databases and QSAR modules, are now available for predictive modelling of inter-individual …

Clearance and beyond: the complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI)

ZH Endre, JW Pickering… - American Journal of …, 2011 - journals.physiology.org
Acute kidney injury (AKI) is a common and frequently fatal illness in critically ill patients. The
reliance on daily measurements of serum creatinine as a surrogate of glomerular filtration …

Estimating the glomerular filtration rate in obese adult patients for drug dosing

MP Pai - Advances in chronic kidney disease, 2010 - Elsevier
One-third of adult Americans are currently classified as obese. Physiologic changes
associated with obesity can potentially alter the clearance of commonly used drugs …

A review of the clinical pharmacokinetics and pharmacodynamics of varenicline for smoking cessation

HM Faessel, RS Obach, H Rollema, P Ravva… - Clinical …, 2010 - Springer
Abstract Varenicline tartrate (Chantix®/Champix®) is a selective partial agonist of the α 4 β 2
nicotinic acetylcholine receptor and is approved as an aid to smoking cessation. The usual …