γ-Secretase in Alzheimer's disease
JY Hur - Experimental & molecular medicine, 2022 - nature.com
Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …
Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective
RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …
humans, but still no curative treatment has been developed. Although many explicative …
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
The role of astrocytes in amyloid production and Alzheimer's disease
GR Frost, YM Li - Open biology, 2017 - royalsocietypublishing.org
Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
G Calabrese, C Molzahn, T Mayor - Journal of Biological Chemistry, 2022 - ASBMB
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
APP processing in Alzheimer's disease
Y Zhang, R Thompson, H Zhang, H Xu - Molecular brain, 2011 - Springer
An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …
Proteolytic processing of Alzheimer's β‐amyloid precursor protein
H Zhang, Q Ma, Y Zhang, H Xu - Journal of Neurochemistry …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …
Biology and pathophysiology of the amyloid precursor protein
H Zheng, EH Koo - Molecular neurodegeneration, 2011 - Springer
The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …
The γ-secretase complex: from structure to function
One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …
Regulated intramembrane proteolysis–lessons from amyloid precursor protein processing
SF Lichtenthaler, C Haass… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 117, 779–796. Abstract Regulated intramembrane proteolysis (RIP)
controls the communication between cells and the extracellular environment. RIP is …
controls the communication between cells and the extracellular environment. RIP is …