The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
HF Kildegaard, D Baycin-Hizal, NE Lewis… - Current opinion in …, 2013 - Elsevier
Chinese hamster ovary (CHO) cells are the primary factories for biopharmaceuticals
because of their capacity to correctly fold and post-translationally modify recombinant …
because of their capacity to correctly fold and post-translationally modify recombinant …
An'omics approach towards CHO cell engineering
P Datta, RJ Linhardt… - Biotechnology and …, 2013 - Wiley Online Library
Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial
production of biopharmaceutical products, such as monoclonal antibodies, human growth …
production of biopharmaceutical products, such as monoclonal antibodies, human growth …
[HTML][HTML] Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome
Chinese hamster ovary (CHO) cells, first isolated in 1957, are the preferred production host
for many therapeutic proteins. Although genetic heterogeneity among CHO cell lines has …
for many therapeutic proteins. Although genetic heterogeneity among CHO cell lines has …
[HTML][HTML] CHO microRNA engineering is growing up: Recent successes and future challenges
Abstract microRNAs with their ability to regulate complex pathways that control cellular
behavior and phenotype have been proposed as potential targets for cell engineering in the …
behavior and phenotype have been proposed as potential targets for cell engineering in the …
The use of 'Omics technology to rationally improve industrial mammalian cell line performance
AM Lewis, NR Abu‐Absi, MC Borys… - Biotechnology and …, 2016 - Wiley Online Library
Biologics represent an increasingly important class of therapeutics, with 7 of the 10 top
selling drugs from 2013 being in this class. Furthermore, health authority approval of …
selling drugs from 2013 being in this class. Furthermore, health authority approval of …
Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate
Background To study the role of microRNA (miRNA) in the regulation of Chinese hamster
ovary (CHO) cell growth, qPCR, microarray and quantitative LC-MS/MS analysis were …
ovary (CHO) cell growth, qPCR, microarray and quantitative LC-MS/MS analysis were …
[HTML][HTML] A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques
M Nguyen, A Zimmer - Biotechnology Advances, 2023 - Elsevier
Chinese hamster ovary (CHO) cells are the preferred mammalian host for the large-scale
production of recombinant proteins in the biopharmaceutical industry. Research endeavors …
production of recombinant proteins in the biopharmaceutical industry. Research endeavors …
Detection of host cell microprotein impurities in antibody drug products
Chinese hamster ovary (CHO) cells are used to produce almost 90% of therapeutic
monoclonal antibodies (mAbs) and antibody fusion proteins (Fc-fusion). The annotation of …
monoclonal antibodies (mAbs) and antibody fusion proteins (Fc-fusion). The annotation of …
Tracing production instability in a clonally derived CHO cell line using single‐cell transcriptomics
I Tzani, N Herrmann, S Carillo… - Biotechnology and …, 2021 - Wiley Online Library
A variety of mechanisms including transcriptional silencing, gene copy loss, and increased
susceptibility to cellular stress have been associated with a sudden or gradual loss of …
susceptibility to cellular stress have been associated with a sudden or gradual loss of …
Label‐free mass spectrometric analysis of the mdx‐4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy …
Proteomic profiling plays a decisive role in the identification of novel biomarkers of muscular
dystrophy and the elucidation of new pathobiochemical mechanisms that underlie …
dystrophy and the elucidation of new pathobiochemical mechanisms that underlie …