There are more cases of tuberculosis in the world today than at any other time in history. The
global epidemic has generated intense interest into the immunological mechanisms that …

The continuing HIV/AIDS epidemic and the spread of multi-drug resistant Mycobacterium
tuberculosis has led to the perpetuation of the worldwide tuberculosis epidemic. While M …

Greater understanding of the complex host responses induced by type 1 interferon (IFN)
cytokines could allow new therapeutic approaches for diseases in which these cytokines are …

Introduction CD8+ T cell responses focus on a small fraction of total pathogen-encoded
peptides, which are similar among individuals with shared major histocompatibility complex …

Cell-mediated immunity stems from the proliferation of naive T lymphocytes expressing T
cell antigen receptors (TCRs) specific for foreign peptides bound to host major …

CD4+ T cells are vital for host defense and immune regulation. However, the fundamental
role of CD4 itself remains enigmatic. We report seven patients aged 5–61 years from five …

Horizontal transmission of cytomegaloviruses (CMV) occurs via prolonged excretion from
mucosal surfaces. We used murine CMV (MCMV) infection to investigate the mechanisms of …

CD8+ T cell recognition of virus-infected cells is characteristically restricted by major
histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction …

Coxiella burnetii, the causative agent of Q fever, is a Gram-negative intracellular bacterium
transmitted via aerosol. Regulatory approval of the Australian whole-cell vaccine Q-VAX® in …

Regulation of the adaptive immune response is critical for health. Regulatory activity can be
found in multiple components of the immune system, however, the focus on particular …