Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

The mechanisms of Hedgehog signalling and its roles in development and disease

J Briscoe, PP Thérond - Nature reviews Molecular cell biology, 2013 - nature.com
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Small effects: The indispensable foundation for a cumulative psychological science

FM Götz, SD Gosling… - … on psychological science, 2022 - journals.sagepub.com
We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …

Variable prediction accuracy of polygenic scores within an ancestry group

H Mostafavi, A Harpak, I Agarwal, D Conley… - elife, 2020 - elifesciences.org
Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

RE Mukamel, RE Handsaker, MA Sherman, AR Barton… - Science, 2021 - science.org
Many human proteins contain domains that vary in size or copy number because of variable
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …

[HTML][HTML] The righteous mind: Why good people are divided by politics and religion

J Haidt - New York Pantheon, 2012 - biblio.sg
NEW YORK TIMES BESTSELLER• The# 1 bestselling author of The Anxious Generation
and acclaimed social psychologist challenges conventional thinking about morality, politics …

Adult height, nutrition, and population health

JM Perkins, SV Subramanian, G Davey Smith… - Nutrition …, 2016 - academic.oup.com
In this review, the potential causes and consequences of adult height, a measure of
cumulative net nutrition, in modern populations are summarized. The mechanisms linking …

Disease variants alter transcription factor levels and methylation of their binding sites

MJ Bonder, R Luijk, DV Zhernakova, M Moed… - Nature …, 2017 - nature.com
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …

Common SNPs explain a large proportion of the heritability for human height

J Yang, B Benyamin, BP McEvoy, S Gordon… - Nature …, 2010 - nature.com
SNPs discovered by genome-wide association studies (GWASs) account for only a small
fraction of the genetic variation of complex traits in human populations. Where is the …

Rare and common variants: twenty arguments

G Gibson - Nature Reviews Genetics, 2012 - nature.com
Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …