Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
The mechanisms of Hedgehog signalling and its roles in development and disease
J Briscoe, PP Thérond - Nature reviews Molecular cell biology, 2013 - nature.com
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …
decades ago inaugurated a field that has diversified to encompass embryonic development …
Small effects: The indispensable foundation for a cumulative psychological science
FM Götz, SD Gosling… - … on psychological science, 2022 - journals.sagepub.com
We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …
likely determined by a multitude of causes and that any individual cause is likely to have …
Variable prediction accuracy of polygenic scores within an ancestry group
Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …
based on genome-wide association studies (GWAS) for phenotypic prediction. However …
Protein-coding repeat polymorphisms strongly shape diverse human phenotypes
Many human proteins contain domains that vary in size or copy number because of variable
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …
[HTML][HTML] The righteous mind: Why good people are divided by politics and religion
J Haidt - New York Pantheon, 2012 - biblio.sg
NEW YORK TIMES BESTSELLER• The# 1 bestselling author of The Anxious Generation
and acclaimed social psychologist challenges conventional thinking about morality, politics …
and acclaimed social psychologist challenges conventional thinking about morality, politics …
Adult height, nutrition, and population health
JM Perkins, SV Subramanian, G Davey Smith… - Nutrition …, 2016 - academic.oup.com
In this review, the potential causes and consequences of adult height, a measure of
cumulative net nutrition, in modern populations are summarized. The mechanisms linking …
cumulative net nutrition, in modern populations are summarized. The mechanisms linking …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
Common SNPs explain a large proportion of the heritability for human height
J Yang, B Benyamin, BP McEvoy, S Gordon… - Nature …, 2010 - nature.com
SNPs discovered by genome-wide association studies (GWASs) account for only a small
fraction of the genetic variation of complex traits in human populations. Where is the …
fraction of the genetic variation of complex traits in human populations. Where is the …
Rare and common variants: twenty arguments
G Gibson - Nature Reviews Genetics, 2012 - nature.com
Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …