Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Kidney disease represents a serious global health problem. One of the main concerns is its
late diagnosis, only feasible in a progressed disease state. The lack of a clinical …

Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to
immune system dysregulation, abnormal activation and processing of cell-death signals …

Significance: Innate and adaptive immunity play fundamental roles in the development of
hypertension and its complications. As effectors of the cell-mediated immune response …

Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function
of an organism. The excessive levels of OS mediators may lead to major damage within the …

The importance of the immune system in hypertension, vascular disease, and renal disease
has been appreciated for over 50 years. Recent experimental advances have led to a …

Hydroxychloroquine has been shown to be efficacious in the treatment of autoimmune
diseases, including systemic lupus erythematosus. Hydroxychloroquine-treated lupus …

Oxidative stress has been implicated in a wide range of pathological conditions. The
transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) exerts a central role in …

One of the mechanisms responsible for blood pressure (BP) regulation is thought to be
oxidative stress. In this review, we highlight preclinical studies that strongly support a role for …

Several studies suggest a link between autoimmunity and essential hypertension in
humans. However, whether autoimmunity can drive the development of hypertension …