Formalized rules for protein-protein interactions have recently been introduced to represent
the binding and enzymatic activities of proteins in cellular signaling. Rules encode an …

In this paper, kinetic modeling techniques for complex chemical processes are reviewed.
After a brief historical overview of chemical kinetics, an overview is given of the theoretical …

Rule-based modeling involves the representation of molecules as structured objects and
molecular interactions as rules for transforming the attributes of these objects. The approach …

Managing the overwhelming numbers of molecular states and interactions is a fundamental
obstacle to building predictive models of biological systems. Here we introduce the Network …

BioNetGen allows a user to create a computational model that characterizes the dynamics of
a signal transduction system, and that accounts comprehensively and precisely for specified …

The goal of this series is to offer a survey of the latest literature for clinicians and scientists
alike, providing a list of important recent advances relevant to the broad field of allergy and …

Many activities of cells are controlled by cell‐surface receptors, which in response to
ligands, trigger intracellular signaling reactions that elicit cellular responses. A hallmark of …

The process of signalling through receptors of the immune system involves highly connected
networks of interacting components. Understanding the often counter-intuitive behaviour of …

Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …

The interaction of Abs with their specific FcRs is of primary importance in host immune
effector systems involved in infection and inflammation, and are the target for immune …