Hepatic fibrosis and cirrhosis cause strong human suffering and necessitate a monetary
burden worldwide. Therefore, there is an urgent need for the development of therapies. Pre …

SARS-CoV-2 is a type of beta-CoV that develops acute pneumonia, which is an
inflammatory condition. A cytokine storm has been recognized as one of the leading causes …

Ulcerative colitis (UC) is usually a mildly active disease; however, it can be associated with
serious systemic complications. The current study was undertaken to evaluate the anti …

Hepatic encephalopathy (HE) is a serious neuropsychiatric syndrome due to either acute or
chronic hepatic failure. This study aimed to investigate the possible neuroprotective effect of …

Cyclophosphamide (CP) is a chemotherapeutic agent that induces oxidative stress causing
multiple organ damage. Sacubitril/valsartan, is a combined formulation of neprilysin inhibitor …

Highlights•SB protected against TAA-induced hepatic encephalopathy in rats.•SB decreased
serum NO, reduced hepatic and brain MDA, elevated GSH and SOD.•SB decreased brain …

Cyclophosphamide (CP)-induced lung toxicity is a remaining obstacle against the beneficial
use of this chemotherapeutic agent. More considerations were given to the role of Alogliptin …

Hyperammonemia is a serious metabolic disorder associating with hepatic encephalopathy
(HE) which occurs secondary to several forms of liver injury ranging from simple acute liver …

Abstract Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-
inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated …

Major depressive disorder (MDD) has a complex etiology and is characterized by a change
in mood and psychophysiological state. MDD has been shown to mediate accelerated …